Tests detected 74,592 new cases, taking the national count to 15,433,989, said the ministry.
Brazil has the world's second-highest COVID-19 death toll, after the United States, and the third-largest caseload, behind the United States and India.
The country sees the second wave of an outbreak in 2021, increasing cases and deaths, and surging COVID-19 patients have overwhelmed numerous hospitals.
According to the ministry, Brazil now has a death rate of 204.8 per 100,000 inhabitants and an incidence rate of 7,344.4 per 100,000.
Local media reported that as of Wednesday, 55.8 million people had been vaccinated against COVID-19 in Brazil, with 37.19 million having received the first dose and 18.65 million fully vaccinated.