Santos, a 34-year-old Republican elected in last year's midterm elections to represent New York's 3rd congressional district, tweeted earlier in the day, "I will NOT resign!"
A group of Republicans -- including Congressman Anthony D'Esposito, who represents New York's 4th congressional district -- urged Santos to quit on Wednesday.
D'Esposito said in a statement that Santos' "many hurtful lies and mistruths surrounding his history have irreparably broken the trust of the residents he is sworn to serve."
"For his betrayal of the public's trust, I call on Congressman George Santos to resign," D'Esposito added.
Late last year, Santos admitted to lying about his educational history and professional biography following an investigation by The New York Times. "My sins here are embellishing my resume. I'm sorry," Santos acknowledged that time.
'This joke’s gotta go' — Members of the Nassau County GOP on Long Island called for the resignation of 'pathological liar' George Santos (R-NY), saying he 'disgraced the House of Representatives' pic.twitter.com/AEoMXXzK5J
It is common for U.S. politicians to lie about their life stories and policy proposals to court support. Senator Marco Rubio of Florida, re-elected to a third term last year, built his political prominence by portraying his parents as exiles from their native Cuba.
However, The Washington Post published in 2011 found that the Republican's account "embellishes the facts" and that "the real story of his parents' migration appears to be a more conventional immigrant narrative."
Herschel Walker campaigned against abortion access in 2022 as the Republican nominee for U.S. Senate in Georgia. But his former girlfriends have accused him of encouraging or paying for abortion.
Senator Elizabeth Warren, a Massachusetts Democrat who ran for the White House several years ago, issued a public apology in 2019 for her past claims of Native American ancestry.
"Washington has created a culture where it's acceptable to lie to further your own interest," former U.S. Congresswoman and Fox News contributor Tulsi Gabbard commented while reacting to Santos' scandal.
"But even when politicians do get caught, people just shrug their shoulders and move on. So, no one should be surprised that the American people don't trust these politicians."