The news came out Thursday as part of the investigations into the vice president's business ties with Colombian drug trafficker Guillermo Acevedo, alias "Memo Fantasma".
Ramirez kept this information hidden from her voters during the electoral campaign that led her to the vice presidency.
On Friday, after news of the imprisonment of Ramirez's brother, and the payment of thousands of dollars for his bail, Colombia's opposition senators demanded her resignation.
She is @mluciaramirez Vice President of Colombia, she is talking about fighting Drug Traffic, but she has an scandal in Colombia because her connections with a NARCO alias Memo Fantasma. Also she paid the bail for her brother in Florida, accused of being a Heroin dealer. @POTUShttps://t.co/RnI7HLhJqI