Ndayishimiye instituted five female-led ministries, as Justice; Civil Service, Labor, and Employment; Trade, Transport, Industry, and Tourism; and Communication, as well as Information Technology and the Media office.
Human rights defender Imelde Sabushimike assumed Solidarity, Social Affairs, and Human Rights' portfolio. She is the first Batwa indigenous community member in Burundi's Ministers Council.
President Ndayishimiye retained Gervais Ndirakobuca as the interior ministry. The functionary was the general administrator of the National Intelligence Service during the prior mandate.