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Israeli warplanes have regularly hit positions for the Syrian army inside Syria over the past seven years, breaking international law and escalating tensions.
An Israeli missile hit Syria's Quneitra province causing casualties and damaging a military vehicle, Syrian state media said on Monday.
A Syrian military source was cited by state news agency SANA as saying "the Israeli enemy targeted one of our military positions" in Quneitra province, which is adjacent to the Israeli-occupied Golan Heights.
It said one soldier was killed, another injured and a military vehicle damaged.
Last year, the anti-aircraft fire brought down an Israeli jet returning from an air raid in Syria, prompting a wave of Israeli strikes against other targets there.
Israel has acknowledged carrying out hundreds of strikes in recent years to curtail the influence of its arch-foe Iran and Tehran's Lebanese ally Hezbollah, which are fighting on the side of President Bashar al-Assad in Syria's war.