Despite regular condemnation from critics, Israel continues to build illegal settlements in occupied territory, prompting clashes.
The man was identified as 20 year-old Ahmed Ibrahim Jaber al-Najjar, while a second man was also injured by Israeli soldiers.
The two men were shot at after allegedly throwing Molotov cocktails at Israeli settler vehicles near the village of Burin.
An Israeli military spokeswoman said soldiers saw two Palestinians throwing objects towards a road near the Palestinian city of Nablus and "identifying an immediate threat shot toward the suspects' lower extremities.”
Israel has continued to build illegal Jewish settlements throughout the West Bank, prompting clashes between the resident Palestinians and the Israeli settlers.
The United Nations recently condemned Israel for demolishing 77 Palestinian homes and displacing dozens of families in the West Bank.
In 2014 alone, Israel approved nearly 17,000 new illegal housing units on Palestinian land in 2014.
Peace talks between the Israelis and Palestinians broke down in April of 2014. Palestinian President Mahmoud Abbas has since stepped up moves at the United Nations towards Palestinian statehood, including submitting a successful application to become a member of the International Criminal Court.
That move provoked the ire of Israel, who fear Israelis will be brought before the court to answer for alleged war crimes committed against Palestinians.