According to local authorities, the fire spread due to the heat and wind gusts of over 90 kilometers per hour.
Hundreds of firefighters deployed in the El Bolson area are trying to control the flames with two helicopters and one plane's help.
"The flames threaten to cross the border into the neighboring Chubut Province," Rio Negro Governor Arabela Carreras explained, highlighting the complexity faced by firefighters in putting out the blaze.
Active fire detected in Aguirre Department, Santiago del Estero Province, Argentina lat/lon: -29.4723, -62.0228 Time: 2021-01-25 (14:02 UTC) pic.twitter.com/mR0kget1JI
"El Bolson is a mountainous area, and firefighters have no access to water refill," she said, adding that two families had to be evacuated after their homes were destroyed by the fire on Thursday.
According to local outlets, the hypothesis of the fire outbreak is that a neighbor left the fire unextinguished after making a barbecue.
"We have verified that theory from the air. The place where the fire started is a residence," Carreras stated after flying over the area affected by the "largest fire registered in the Patagonia region so far."
Local officials said they will investigate whether the fire was intentional. Meanwhile, they hope the blaze eases in the next few hours, as temperatures are expected to drop.